OBM Geriatrics

(ISSN 2638-1311)

OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.

Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.

Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.

Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 8 days from acceptance to publication (median values for papers published in this journal in 2020, 1-2 days of FREE language polishing time is also included in this period). 

Open Access Research Article

Translation and Validation of “Brief Bedside Dysphagia Screening Test” in a Greek Sample of Neurological Patients

Received: 09 October 2020;  Published: 02 April 2021;  doi: 10.21926/obm.geriatr.2102165

Abstract

Background. Dysphagia may be a threatening condition if not diagnosed and treated early. Healthcare professionals need simple, quick and reliable tools for their daily clinical practice to be able to evaluate it immediately. The purpose of the present study was the translation and validation of t [...]

Open Access Original Research

Molecular Basis of Allogeneic Pluripotent Stem Cell Treatment of a Patient with Sporadic ALS

Received: 21 August 2020;  Published: 29 March 2021;  doi: 10.21926/obm.geriatr.2101164

Abstract

There are no curative strategies for ALS, and as a result the alternative therapies are gaining ground, in particular the stem cell-based therapies which hold a promising future. Here we describe an ALS patient, who by choice, received allogeneic human cord-blood derived multipotent stem cells (MSC) [...]

Open Access Original Research

Routines and Structure in the Assessment of Visuospatial Neglect in Rehabilitation Facilities: Current Practice in the Netherlands and the United Kingdom

Received: 07 December 2020;  Published: 19 March 2021;  doi: 10.21926/obm.geriatr.2101163

Abstract

Visuospatial neglect (VSN) adversely impacts both the length of rehabilitation and activities of daily living (ADL) of patients after stroke and can reduce their participation in community activities. Therefore, it is important to assess VSN after stroke in neurorehabilitation facilities. The proces [...]

Open Access Perspective

Research Recommendations to Address Dementia Workforce Development Needs

Received: 12 November 2020;  Published: 16 March 2021;  doi: 10.21926/obm.geriatr.2101162

Abstract

This policy paper presents workforce development recommendations for research, clinical care and public stakeholders as they plan future research activities to strengthen the workforce to support the healthcare and social needs of persons living with dementia and their families and caregivers. To cr [...]

Open Access Review

Pharmacological Management of Spontaneous Intracerebral Hemorrhage in Older Adults

Received: 11 February 2021;  Published: 16 March 2021;  doi: 10.21926/obm.geriatr.2101161

Abstract

Pharmacological management of intracerebral hemorrhage in adult patients over 65 years of age requires special considerations due to differing clinical presentations, underlying organ dysfunction, and more complex medical histories and medication profiles. A literature review of articles focusing on [...]

Open Access Research Article

Spousal Dementia Grief: A Research Report from the Two-Track Model of Dementia Grief Project

Received: 07 September 2020;  Published: 12 March 2021;  doi: 10.21926/obm.geriatr.2101160

Abstract

Caregiving for a loved one suffering from cognitive decline involves coping with many challenges and losses. This experience increases the risk of worsening the physical and mental health of the caregiver and has been the subject of a substantial number of studies focusing on the stress and burden o [...]

Open Access Research Article

Acute Care Decision-Making for Patients with Advanced Dementia: An Exploratory Study Using Cognitive Task Analysis

Received: 11 November 2020;  Published: 01 March 2021;  doi: 10.21926/obm.geriatr.2101159

Abstract

Decision-making by medical and health care staff forms the core of professional practice. Thought processes, including non-clinical considerations, significantly impact how clinical decisions are made. Such considerations become more relevant when addressing end-of-life care decisions for patients w [...]

Open Access Original Research

A Preliminary Investigation of Relationships among Pharyngeal Acidity, Dysphagia, and Pneumonia in Acute Stroke

Received: 29 October 2020;  Published: 22 February 2021;  doi: 10.21926/obm.geriatr.2101158

Abstract

Individuals with acute stroke on nonoral feeding regimens frequently develop pneumonia, questioning the long-held belief that pneumonia in stroke patients is a caused by food and liquid aspiration alone. Refluxate and colonized oral secretions are thought to contribute to an acidic oropharyngeal env [...]

Open Access Case Report

Dysphagia Aortica: A Case Report and Review of Treatment Options

Received: 29 October 2020;  Published: 05 February 2021;  doi: 10.21926/obm.geriatr.2101157

Abstract

A 64-year-old, cachectic man with body mass index (BMI) <19 visited in clinic with the chief complaint of dysphagia for 6 months. He reported a 2-year history of reflux and heartburn, for which he has been taking pantoprazole but reported only 40% relief of reflux symptoms. He reported progressiv [...]

Open Access Review

Telomerase and Cancer: A Complex Relationship

Received: 26 October 2020;  Published: 03 February 2021;  doi: 10.21926/obm.geriatr.2101156

Abstract

Telomere elongation is protective of genomic stability, whereas telomere shortening increases genomic instability and thereby increases cancer risk. Long telomeres lower the risk of clinical cancer, while short telomeres are part of a causal cascade of intracellular events that result in oncogenesis [...]

Open Access Opinion

Yoga: A Potential Adjunct Therapy to Current Rehabilitation Pathways in Cardiac Conditions and Stroke

Received: 06 August 2020;  Published: 28 January 2021;  doi: 10.21926/obm.geriatr.2101155

Abstract

Yoga is a form of movement-based mindfulness practice that enhances the mind-body connection to benefit overall health and well-being. Although the practices of yoga are ancient traditions in the Buddhist and Hindu philosophies, scientific research regarding the impacts of yoga among people with poo [...]

Open Access Review

Dysphagia in Inclusion Body Myositis, A Disease of the Elderly

Received: 11 November 2020;  Published: 21 January 2021;  doi: 10.21926/obm.geriatr.2101154

Abstract

Inclusion body myositis is one of the most common acquired myopathies seen in the aging population. The muscle weakness is of insidious onset, frequently starting in the legs, but over time gradually progresses to eventually involve all skeletal muscles of the limbs, face, swallowing and respiratory [...]

Open Access Research Article

Which Physiological Swallowing Parameters Change with Healthy Aging?

Received: 24 November 2020;  Published: 19 January 2021;  doi: 10.21926/obm.geriatr.2101153

Abstract

Research suggests there are age-related changes in swallowing that do not constitute impairment (“presbyphagia”). The goal of this study was to explore the influence of age on quantitative measures of healthy swallowing by controlling for the effects of sex and sip volume in order to determine [...]

Open Access Original Research

Knowledge of Osteoporosis and Lifestyle Behaviours Impacting Peak Bone Mass among Young Adults

Received: 27 July 2020;  Published: 11 January 2021;  doi: 10.21926/obm.geriatr.2101152

Abstract

Osteoporosis is a major public health problem through its association with fragility fracture. Low peak bone mass (PBM) is a major contributor to later osteoporosis risk. Despite this, most studies concentrate on older people when the window of opportunity to impact PBM has passed. This study aimed [...]

Open Access Research Article

Stepping Out: A Pilot Program to Reduce Falls Risk in People with Mild Cognitive Impairment

Received: 14 September 2020;  Published: 08 January 2021;  doi: 10.21926/obm.geriatr.2101151

Abstract

Cognitive impairment significantly increases the risk of accidental falls in older adults, and falls outcomes are more severe in this population. However, few interventions exist to reduce falls among individuals with cognitive impairment. To address this gap, we developed Stepping Out, [...]

Open Access Perspective

Relax into Yoga for Seniors: An Evidence-Informed Update for Enhancing Yoga Practice Benefits by Reducing Risk in a Uniquely Vulnerable Age Group

Received: 13 August 2020;  Published: 07 January 2021;  doi: 10.21926/obm.geriatr.2101150

Abstract

Teaching yoga to seniors is often considered an entry-level job for a yoga instructor since older adults are unlikely to attempt complicated, “advanced” postures. Unfortunately, this ill-informed attitude puts the most vulnerable students with the least-trained instructors who may unknowingly put th [...]

Open Access Editorial

Acknowlegement to Reviewers of OBM Geriatrics in 2020

Received: 04 January 2021;  Published: 06 January 2021;  doi: 10.21926/obm.geriatr.2101149

Abstract

The editors of OBM Geriatrics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions throug [...]

Open Access Research Article

Feasibility of Implementing Therapeutic Yoga in Assisted Living Facilities

Received: 19 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101148

Abstract

The purpose of this convergent mixed methods study was to explore the feasibility of implementing a chair yoga intervention in assisted living facilities (ALFs), evaluating reach, demand, acceptability, practicality, treatment fidelity, and safety. A yoga intervention was implemented twice a week fo [...]

Open Access Research Article

Yoga Training Impacts Physical Function 12 Months Post Intervention for Care Partners of those with Mild Cognitive Impairment

Received: 30 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101147

Abstract

Physical exercise has been demonstrated to help maintain cognition in people with Mild Cognitive Impairment (pwMCI). We previously demonstrated yoga’s benefit in maintenance of memory related activities of daily living in pwMCI. Our research also has shown yoga helps sustain positive psychological w [...]

Open Access Review

Spotlight on Older Adults in Swallowing Research

Received: 07 November 2020;  Published: 25 December 2020;  doi: 10.21926/obm.geriatr.2004146

Abstract

Generalisations and misconceptions about ageing and swallowing can influence clinical opinion. Assumptions about swallowing function based on someone’s age risk overmedicalising or, conversely, undertreating older patients. Evidence suggests that increased prevalence of swallowing problems in older [...]

Open Access Case Report

Anticoagulation Rationale in an Elderly Patient with Stroke, Cerebral Amyloid Angiopathy, and Antiphospholipid Syndrome: A Case Report

Received: 29 September 2020;  Published: 24 December 2020;  doi: 10.21926/obm.geriatr.2004145

Abstract

We present a case of a 74-year-old woman with deep intracerebral hemorrhage (ICH), probable cerebral amyloid angiopathy (CAA), and probable antiphospholipid syndrome (APS). Due to the high hemorrhagic risk, it was decided not to use anticoagulants. In a period of three months, she had two separate c [...]

Open Access Research Article

Perceived Psychosocial Benefits for Individuals with Parkinson’s Disease Following Therapeutic Yoga: A Qualitative Analysis

Received: 19 August 2020;  Published: 22 December 2020;  doi: 10.21926/obm.geriatr.2004144

Abstract

Using a qualitative approach, this study explored the perceived impacts of a therapeutic yoga intervention for individuals with Parkinson’s disease (PD), and examined the beneficial components of the intervention. Eighteen individuals with PD who completed an eight-week yoga intervention participate [...]

Open Access Research Article

Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Amyotrophic Lateral Sclerosis

Received: 12 October 2020;  Published: 17 December 2020;  doi: 10.21926/obm.geriatr.2004143

Abstract

Amyotrophic lateral sclerosis (ALS) is reported to be probably linked to frontotemporal lobar degeneration (FTLD). Since FTLD is characterized by severe frontotemporal degeneration along with hippocampal atrophy (HA), the present study used post-mortem 7.0-tesla magnetic resonance imaging to investi [...]

Open Access Research Article

Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathy

Received: 24 September 2020;  Published: 10 December 2020;  doi: 10.21926/obm.geriatr.2004142

Abstract

Purpose: The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (M [...]

Open Access Short Communication

An Algorithm to Optimize Pain Detection and Management in Older Patients in Routine Practice

Received: 09 July 2020;  Published: 07 December 2020;  doi: 10.21926/obm.geriatr.2004141

Abstract

Acute or persistent pain is a common occurrence and is often undertreated in older patients, especially those with an inability to communicate verbally (ICV). Regular comprehensive pain assessment, including self-rating and/or behavior scales, is critical but difficult to implement in routine clinic [...]

13th Clinical Trials on Alzheimer's Disease (CTAD)

November 4-7, 2020, Boston, USA

The development of the next generation of Alzheimer’s disease treatments is among the most important health needs worldwide, but presents huge challenges. The goal of the meeting is to bring together today’s worldwide leaders in the treatment of Alzheimer’s disease to discuss new results, candidate therapeutics, and methodological issues important to the development of the next generation of Alzheimer’s disease treatments.

Clinical trial teams from worldwide centers will report on their efforts to identify new biomarkers of disease as well as more sensitive clinical assessment tools to identify those at risk for AD, to predict progression, and assess the effectiveness of new treatments.

For more details, please visit: https://www.ctad-alzheimer.com/ctad-2020

Alzheimer's Association International Conference®

July 26-30, 2020, Amsterdam, Netherlands

AAIC 2020 will bring together international investigators, clinicians and care researchers to discuss the latest studies, theories and discoveries that will help bring the world closer to breakthroughs in dementia science.

For more details, please visit: https://www.alz.org/aaic/overview.asp

Integrative Regen Group

February 29- March 2, 2020, Arizona Biltmore Resort, USA

Who: Providers of all disciplines who are passionate about or interested in regenerative medicine are encouraged to attend this event. The agenda will be packed full of actionable topics that most attendees will be able to put into effect immediately to continue to provide their patients with the most cutting-edge therapies.

What: Integrative Regen Group’s second conference will be bringing together experts in all areas of regenerative medicine, from stem cells to photobiomodulation, peptides to hormones, and everything in between. It is our goal that every person in attendance increase their knowledge base substantially.

For more details, please visit: https://www.intregengroup.com/

The 2nd Longevity Therapeutics

January 28-30, 2020, San Francisco CA, USA

With rapid advances in the understanding of the underlying biology and mechanisms of aging, ground-breaking research and technology are coming together to target aging pathways, in a way to prevent, reverse or delay the onset of age-related conditions, and consequently improve heathspan.

The 2nd Longevity Therapeutics 2020 Summit will once again bring together 80+ leading experts in aging-related research, including biotechs, pharma, academics and investors, who are committed to serving worldwide population with innovative drugs to prevent, delay and treat age-related conditions.

For more details, please visit: https://longevity-therapeutics.com/

OBM Geriatrics welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

Register and Submit now.

Newsletter
Highlight

Highlight

by Michael Fossel

OBM Geriatrics 2021

Published: 15 January 2020

Highlight from: A unified model of dementias and age‐related neurodegeneration.

Michael Fossel.

Alzheimer’s & Dementia.

doi: 10.1002/alz.12012.

Highly Accessed Articles

Case Report

by Garuth Chalfont et al.

OBM Geriatrics 2021

Published: 07 August 2019

Perspective

by Robert Conder et al.

OBM Geriatrics 2021

Published: 20 March 2019

Review

by Michael Fossel

OBM Geriatrics 2021

Published: 15 February 2019

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