Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathy
OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.
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Cerebrovascular Biomarkers in Alzheimer's Disease
Submission Deadline: April 15, 2021 (Open) Submit Now
Jacques De Reuck, MD, PhD
Professor, Université Lille 2, INSERM U1171 Degenerative & Vascular Cognitive Disorders, Lille, France
Research Interests: Dementia; cognitive impairment; Alzheimer's disease; ischemic stroke; neurodegenerative diseases; cerebrovascular diseases; vascular dementia
About This Topic
The significance of small cerebrovascular lesions is frequently overlooked in patients with Alzheimer’s disease. These lesions are most commonly due to cerebral amyloid angiopathy, which is mainly associated in the end-stages of the disease. Also Alzheimer’s disease can be mixed with arteriosclerotic small-vessel disease. The most common small cerebrovascular lesions are cortical micro-bleeds, cortical micro-infarcts, white matter changes, lacunar infarcts and superficial cortical siderosis. These lesions can be best detected with 7.0-tesla magnetic resonance imaging in vivo and on post-mortem examination, when the diagnosis of Alzheimer’s disease has to be confirmed for the family.
The final message is that in patients with suspected Alzheimer’s disease the vascular risk factors, such as arterial hypertension, hypercholesterolemia and diabetes, have to be treated as early as possible and smoking has to be avoided.
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